Researchers are studying an investigational medicine, given as a monthly injection. The Phase 3 clinical trials are looking into how safe and effective the injection is for reducing body weight and helping with weight-related health conditions, specifically for people living with both heart failure and excess weight. This study is exploring whether the investigational medicine can help reduce heart failure-related symptoms and lower the risk of hospitalisation.
In Part 1, participants receive either the investigational medicine or a placebo as a monthly injection. Everyone who completes Part 1 has the option to move into Part 2, where they’ll receive the investigational medicine for two years. Those who choose not to continue into Part 2 will enter a follow-up period instead.
Heart failure is a chronic condition in which the heart is unable to pump blood as efficiently as the body needs, rather than the heart stopping altogether. It can result from the heart muscle being too weak (reduced pumping strength) or too stiff (unable to fill properly with blood). Maintaining a healthy weight reduces this workload, helps keep blood pressure and blood sugar in check, and supports normal heart function. Even modest weight loss can ease strain on the heart and lower the risk of developing heart failure over time.
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